Back to Search
Start Over
Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?
- Source :
- Journal of neurochemistryREFERENCES. 158(6)
- Publication Year :
- 2021
-
Abstract
- Cholinergic basal forebrain (cBF) neurons are particularly vulnerable to degeneration following trauma and in neurodegenerative conditions. One reason for this is their characteristic expression of the p75 neurotrophin receptor (p75 ), which is upregulated and mediates neuronal death in a range of neurological and neurodegenerative conditions, including dementia, stroke, and ischaemia. The signalling pathway by which p75 signals cell death is incompletely characterised, but typically involves activation by neurotrophic ligands and signalling through c-jun kinase, resulting in caspase activation via mitochondrial apoptotic signalling pathways. Less well appreciated is the link between conditions of oxidative stress and p75 death signalling. Here, we review the literature describing what is currently known regarding p75 death signalling in environments of oxidative stress and hypoxia to highlight the overlap in signalling pathways and the implications for p75 signalling in cBF neurons. We propose that there is a causal relationship and define key questions to test this assertion.
- Subjects :
- musculoskeletal diseases
Programmed cell death
Basal Forebrain
Nerve Tissue Proteins
Receptors, Nerve Growth Factor
Biology
medicine.disease_cause
Biochemistry
Cellular and Molecular Neuroscience
medicine
Low-affinity nerve growth factor receptor
Animals
Humans
Hypoxia
Basal forebrain
Cell Death
Kinase
biological factors
Hedgehog signaling pathway
Cholinergic Neurons
Oxidative Stress
nervous system
Nerve Degeneration
biology.protein
Cholinergic
Neuroscience
Oxidative stress
Neurotrophin
Subjects
Details
- ISSN :
- 14714159
- Volume :
- 158
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of neurochemistryREFERENCES
- Accession number :
- edsair.doi.dedup.....a4e4ca6d4bd9c18898f9bb73a7b2b46c