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Epithelial Cell Foot Process Effacement in Podocytes in Focal and Segmental Glomerulosclerosis: A Quantitative Analysis
- Source :
- Ultrastructural Pathology. 38:303-308
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- Effacement of the epithelial cell foot processes of glomerular podocytes are thought to be diffuse in the primary form of focal and segmental glomerulosclerosis (FSGS). In contrast, effacements that occur in the secondary form of FSGS are thought to be focal. To evaluate this theory, the extent of epithelial cell foot process effacement was analyzed and compared in podocytes from cases of primary and secondary FSGS.Consecutive cases of adult primary and secondary FSGS that were diagnosed between January 1997 and December 2010 were retrospectively retrieved and analyzed. The electron microscopy materials of all specimens were reviewed. Glomerular podocytes from each sample were counted, recorded and analyzed for the percentage of diffuse versus focal epithelial foot process effacement.Seventeen primary and 16 secondary FSGS specimens were reviewed. In the 17 primary FSGS cases, 35.1% of the podocytes were focally fused, and 64.9% were diffusely fused. In the 16 secondary FSGS cases, 72.1% of the podocytes were focally fused. There were significantly more focally fused podocytes in secondary FSGS than in primary FSGS. In contrast, significantly more diffusely fused podocytes were observed in primary FSGS than in secondary FSGS.This is the first study to perform a quantitative analysis of the extent of epithelial cell foot process effacement in podocytes in primary and secondary FSGS. This study also confirms that the electron microscopic characteristics of the podocyte effacement process can be used to facilitate the diagnosis of primary versus secondary FSGS.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Kidney Glomerulus
Secondary FSGS
urologic and male genital diseases
Pathology and Forensic Medicine
Podocyte
Primary FSGS
Young Adult
Structural Biology
medicine
Humans
Foot Process
Segmental glomerulosclerosis
Child
Glomerulosclerosis, Focal Segmental
Podocytes
urogenital system
Chemistry
Epithelial Cells
Foot process effacement
Middle Aged
female genital diseases and pregnancy complications
Epithelium
Microscopy, Electron
medicine.anatomical_structure
Female
Subjects
Details
- ISSN :
- 15210758 and 01913123
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Ultrastructural Pathology
- Accession number :
- edsair.doi.dedup.....a4bed0898488fd5c5662f61879d21874