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Relative roles of principal and intercalated cells in the regulation of sodium balance and blood pressure
- Source :
- Current hypertension reports. 17(4)
- Publication Year :
- 2015
-
Abstract
- The kidney continuously adapts daily renal excretion of NaCl to match dietary intakes in order to maintain the NaCl content of the body, and keep vascular volume constant. Any situation that leads to NaCl retention favors a rise in blood pressure. The aldosterone-sensitive distal nephron, which contains two main types of cells, principal (PC) and intercalated (IC) cells, is an important site for the final regulation of urinary Na(+) excretion. Research over the past 20 years established a paradigm in which PCs are the exclusive site of Na(+) absorption while ICs are solely dedicated to acid-base transport. Recent studies have revealed the unexpected importance of ICs for NaCl reabsorption. Here, we review the mechanisms of Na(+) and Cl(-) transport in the aldosterone-sensitive distal nephron, with emphasis on the role of ICs in maintaining NaCl balance and normal blood pressure.
- Subjects :
- Epithelial sodium channel
medicine.medical_specialty
AE4
vH+-ATPase
Prostaglandin E2
Sodium
ENaC
chemistry.chemical_element
Blood Pressure
Sodium Chloride
Kidney
Sodium transport
Ndcbe
WNK
chemistry.chemical_compound
Internal medicine
Internal Medicine
Pendrin
Medicine
Animals
Humans
Intercalated Cell
Aldosterone
Animal
business.industry
Reabsorption
Angiotensin II
Medicine (all)
Biological Transport
ATP
Serine protease
medicine.anatomical_structure
Endocrinology
chemistry
Renal physiology
Hypertension
Chloride transport
Paracrine factor
business
Distal nephron
Human
Subjects
Details
- ISSN :
- 15343111
- Volume :
- 17
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Current hypertension reports
- Accession number :
- edsair.doi.dedup.....a4bc3ced7f30dfe5ec29b43851126725