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Prevalence and Concordance of Cutaneous Beta Human Papillomavirus Infection at Mucosal and Cutaneous Sites
- Source :
- The Journal of Infectious Diseases. 216:92-96
- Publication Year :
- 2017
- Publisher :
- Oxford University Press (OUP), 2017.
-
Abstract
- Background Cutaneous beta human papillomavirus (HPV) infection across cutaneous and mucosal tissues within individuals has not been examined. Methods A subcohort of men (n = 87) participating in the HPV Infection in Men (HIM) study provided eyebrow hairs, forearm skin swabs, genital skin swabs, oral rinse samples, and anal swabs. Beta-HPV DNA in the 5 tissues was detected using a multiplex assay, and site-specific beta-HPV prevalence was examined. Results Any beta-HPV was most prevalent in genital skin (81.6%), followed by forearm skin (64.4%), eyebrow hairs (60.9%), oral mucosa (35.6%), and anal mucosa (33.3%). Most prevalent beta-HPV types included HPV-38 (beta-2) in both genital skin (32.2%) and eyebrow hairs (16.1%), HPV-12 (beta-1) in forearm skin (23%) and oral mucosa (9.2%), and HPV-76 (beta-3) in anal mucosa (14.9%). Concordance of any beta-HPV infection was greater (31.0%) across the 3 keratinized tissue sites (genital skin, eyebrow hairs, forearm skin) than across the 2 mucosal sites (anal and oral mucosa, 6.9%). Conclusions Prevalence of beta-HPV varied by anatomic site of infection. Biological properties of beta-HPV types detected at mucosal sites and their role in disease pathogenesis should be examined.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Pathology
Adolescent
Genotyping Techniques
Eyebrow
Anal Canal
Anal Mucosa
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Major Article
Prevalence
Humans
Immunology and Allergy
Medicine
Sex organ
Prospective Studies
Oral mucosa
Papillomaviridae
Aged
Skin
Mucous Membrane
integumentary system
biology
business.industry
Papillomavirus Infections
HPV infection
virus diseases
Mucous membrane
Middle Aged
Anal canal
medicine.disease
biology.organism_classification
Dermatology
female genital diseases and pregnancy complications
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
030220 oncology & carcinogenesis
DNA, Viral
Eyebrows
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 216
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....a4ba7c3444f97913b2d3e6ad8101670e