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Acute toxicological effects of zinc oxide nanoparticles in mice after intratracheal instillation

Acute toxicological effects of zinc oxide nanoparticles in mice after intratracheal instillation

Authors :
Zihong Liu
Tianliang Zhang
Haibo Li
Dejun Wang
Jingyang Zhou
Source :
International Journal of Occupational and Environmental Health. 23:11-19
Publication Year :
2017
Publisher :
Informa UK Limited, 2017.

Abstract

Zinc oxide nanoparticles (ZnO NPs) are increasingly being used in industry.To evaluate the acute toxicology of ZnO NPs in Mice.ZnO NPs were intratracheally instilled into mice at different dose (200, 400, 800 μg/kg), which was 1, 2, or 4 times of accumulative intake in one week according to the threshold limit value. Acute toxicity was assessed by animal mortality, organ/body weight ratios, hematology, blood biochemistry, and histopathology as well as by the determination of cells, proteins, and lactate dehydrogenase activity in bronchoalveolar lavage fluid.Exposure to ZnO NPs also resulted in bodyweight loss and a higher level of total cell number, total protein, and hydroxyproline content in BALF. Nitric oxide and malondialdehyde levels in the lung homogenates were also increased. In addition, inflammatory and hyperplastic changes in the lungs were observed.Threshold limit value (5 mg/m

Details

ISSN :
20493967 and 10773525
Volume :
23
Database :
OpenAIRE
Journal :
International Journal of Occupational and Environmental Health
Accession number :
edsair.doi.dedup.....a4b18ce85865c50c242497022a9041cb
Full Text :
https://doi.org/10.1080/10773525.2016.1278510