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Acute toxicological effects of zinc oxide nanoparticles in mice after intratracheal instillation
Acute toxicological effects of zinc oxide nanoparticles in mice after intratracheal instillation
- Source :
- International Journal of Occupational and Environmental Health. 23:11-19
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Zinc oxide nanoparticles (ZnO NPs) are increasingly being used in industry.To evaluate the acute toxicology of ZnO NPs in Mice.ZnO NPs were intratracheally instilled into mice at different dose (200, 400, 800 μg/kg), which was 1, 2, or 4 times of accumulative intake in one week according to the threshold limit value. Acute toxicity was assessed by animal mortality, organ/body weight ratios, hematology, blood biochemistry, and histopathology as well as by the determination of cells, proteins, and lactate dehydrogenase activity in bronchoalveolar lavage fluid.Exposure to ZnO NPs also resulted in bodyweight loss and a higher level of total cell number, total protein, and hydroxyproline content in BALF. Nitric oxide and malondialdehyde levels in the lung homogenates were also increased. In addition, inflammatory and hyperplastic changes in the lungs were observed.Threshold limit value (5 mg/m
- Subjects :
- Male
inorganic chemicals
0301 basic medicine
Pathology
medicine.medical_specialty
Intratracheal instillation
Pulmonary Fibrosis
Metal Nanoparticles
chemistry.chemical_element
Nanoparticle
Zinc
010501 environmental sciences
Pharmacology
01 natural sciences
Mice
03 medical and health sciences
Administration, Inhalation
mental disorders
medicine
Animals
Lung
health care economics and organizations
0105 earth and related environmental sciences
Mice, Inbred ICR
Lung fibrosis
technology, industry, and agriculture
Public Health, Environmental and Occupational Health
respiratory system
030104 developmental biology
chemistry
Murine model
Zinc Oxide
Original Research Papers
Subjects
Details
- ISSN :
- 20493967 and 10773525
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- International Journal of Occupational and Environmental Health
- Accession number :
- edsair.doi.dedup.....a4b18ce85865c50c242497022a9041cb
- Full Text :
- https://doi.org/10.1080/10773525.2016.1278510