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SPECIFIC BINDING SITES FOR L-TRIIODOTHYRONINE IN RAT LIVER AND KIDNEY CYTOSOL
- Source :
- European Journal of Endocrinology. 82:98-104
- Publication Year :
- 1976
- Publisher :
- Oxford University Press (OUP), 1976.
-
Abstract
- Binding of 125I-labelled triiodothyronine (T3) to rat liver and kidney cytosol was examined. In both organs a very similar binding protein was detected. The apparent equilibrium association constants amounted to 4.8 X 10(7) M-1 for the liver protein and to 1.8 X 10(7) M-1 for the kidney protein. In the two organs a high capacity for T3 binding was observed: maximal binding capacities of respectively 4.3 and 33.2 pmol per mg total cytosol protein. Displacement studies using thyroid hormone analogues showed that the binding exhibited similar specificity.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Kidney
Cytosol
Endocrinology
Internal medicine
medicine
Animals
Binding site
Binding Sites
Triiodothyronine
Chemistry
Binding protein
Thyroid
General Medicine
Rats
medicine.anatomical_structure
Liver
Rat liver
Carrier Proteins
Hormone
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- European Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....a4a8f81d2c071bb19a2cafe65f58acfa