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The effects of postnatal estrogen therapy on brain development in preterm baboons
- Source :
- American journal of obstetrics and gynecology. 204(2)
- Publication Year :
- 2010
-
Abstract
- Estrogen receptors are present within the fetal brain, suggesting that estrogens may exert an influence on cerebral development. Loss of placentally derived estrogen in preterm birth may impair development.Baboons were delivered at 125 days of gestation (term approximately 185 days), randomly allocated to receive estradiol (n = 10) or placebo (n = 8), and ventilated for 14 days. Brains were assessed for developmental and neuropathological parameters.Body and brain weights were not different between groups, but the brain/body weight ratio was increased (P.05) in estradiol-treated animals. There were no differences (P.05) between groups in any neuropathological measure in either the forebrain or cerebellum. There were no intraventricular hemorrhages; 1 estradiol animal displayed ectactic vessels in the subarachnoid space.Brief postnatal estradiol administration to primates does not pose an increased risk of injury or impaired brain development.
- Subjects :
- medicine.medical_specialty
Cerebellum
medicine.drug_class
Estrogen receptor
Placebo
Article
Random Allocation
Internal medicine
biology.animal
medicine
Animals
biology
Estradiol
business.industry
Obstetrics and Gynecology
Brain
Immunohistochemistry
Endocrinology
medicine.anatomical_structure
Estrogen
Forebrain
Linear Models
Gestation
Premature Birth
Subarachnoid space
business
Baboon
Papio
Subjects
Details
- ISSN :
- 10976868
- Volume :
- 204
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American journal of obstetrics and gynecology
- Accession number :
- edsair.doi.dedup.....a499324329438187add6b046e80fb50c