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Transient Activity Induces a Long-Lasting Increase in the Excitability of Olfactory Bulb Interneurons
- Source :
- Journal of Neurophysiology. 99:187-199
- Publication Year :
- 2008
- Publisher :
- American Physiological Society, 2008.
-
Abstract
- Little is known about the cellular mechanisms that underlie the processing and storage of sensory in the mammalian olfactory system. Here we show that persistent spiking, an activity pattern associated with working memory in other brain regions, can be evoked in the olfactory bulb by stimuli that mimic physiological patterns of synaptic input. We find that brief discharges trigger persistent activity in individual interneurons that receive slow, subthreshold oscillatory input in acute rat olfactory bulb slices. A 2- to 5-Hz oscillatory input, which resembles the synaptic drive that the olfactory bulb receives during sniffing, is required to maintain persistent firing. Persistent activity depends on muscarinic receptor activation and results from interactions between calcium-dependent afterdepolarizations and low-threshold Ca spikes in granule cells. Computer simulations suggest that intrinsically generated persistent activity in granule cells can evoke correlated spiking in reciprocally connected mitral cells. The interaction between the intrinsic currents present in reciprocally connected olfactory bulb neurons constitutes a novel mechanism for synchronized firing in subpopulations of neurons during olfactory processing.
- Subjects :
- Olfactory system
Patch-Clamp Techniques
Physiology
Action Potentials
Sensory system
Synaptic Transmission
Article
Afterdepolarization
Rats, Sprague-Dawley
Organ Culture Techniques
Biological Clocks
Interneurons
Sniffing
Muscarinic acetylcholine receptor
Animals
Computer Simulation
Calcium Signaling
Patch clamp
Cortical Synchronization
Chemistry
General Neuroscience
Olfactory Pathways
Olfactory Bulb
Receptors, Muscarinic
Electric Stimulation
Rats
Olfactory bulb
nervous system
Nerve Net
Neuroscience
Subjects
Details
- ISSN :
- 15221598 and 00223077
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Journal of Neurophysiology
- Accession number :
- edsair.doi.dedup.....a483d4629d2beaa8e0cfd94b0dffc2fa
- Full Text :
- https://doi.org/10.1152/jn.00526.2007