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Transient Activity Induces a Long-Lasting Increase in the Excitability of Olfactory Bulb Interneurons

Authors :
Tsuyoshi Inoue
Benjamin W. Strowbridge
Source :
Journal of Neurophysiology. 99:187-199
Publication Year :
2008
Publisher :
American Physiological Society, 2008.

Abstract

Little is known about the cellular mechanisms that underlie the processing and storage of sensory in the mammalian olfactory system. Here we show that persistent spiking, an activity pattern associated with working memory in other brain regions, can be evoked in the olfactory bulb by stimuli that mimic physiological patterns of synaptic input. We find that brief discharges trigger persistent activity in individual interneurons that receive slow, subthreshold oscillatory input in acute rat olfactory bulb slices. A 2- to 5-Hz oscillatory input, which resembles the synaptic drive that the olfactory bulb receives during sniffing, is required to maintain persistent firing. Persistent activity depends on muscarinic receptor activation and results from interactions between calcium-dependent afterdepolarizations and low-threshold Ca spikes in granule cells. Computer simulations suggest that intrinsically generated persistent activity in granule cells can evoke correlated spiking in reciprocally connected mitral cells. The interaction between the intrinsic currents present in reciprocally connected olfactory bulb neurons constitutes a novel mechanism for synchronized firing in subpopulations of neurons during olfactory processing.

Details

ISSN :
15221598 and 00223077
Volume :
99
Database :
OpenAIRE
Journal :
Journal of Neurophysiology
Accession number :
edsair.doi.dedup.....a483d4629d2beaa8e0cfd94b0dffc2fa
Full Text :
https://doi.org/10.1152/jn.00526.2007