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Comparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin
- Source :
- Mutation research. 417(2-3)
- Publication Year :
- 1998
-
Abstract
- 7H-Dibenzo[c,g]carbazole (DBC) is an environmental pollutant that produces DNA adducts and tumors in mouse liver and skin following subcutaneous injection and topical application. The two synthetic derivatives 5,9-dimethyl-DBC (DMDBC) and N7-methyl-DBC (NMDBC) induce tissue-specific lesions. DNA adducts and tumors are observed only in liver following exposure to DMDBC and only in skin following exposure to NMDBC. We used the positive selection MutaMouse model to measure the induction of mutations in the two target organs, 28 days after a single subcutaneous injection or topical application of DBC, DMDBC and NMDBC. In liver, DBC and DMDBC induced 30- to 50-fold increases in mutant frequency (MF), while NMDBC had only a weak effect, regardless of the route of administration. After topical application, DBC and NMDBC produced 3.4- to 7.9-fold increases in MF in skin, while DMDBC had a weak effect. After subcutaneous injection, the three compounds had no or weak effect in skin. This study shows gene mutations arise in the respective target organs in which primary DNA damage and tumors are observed. These results illustrate the relevance of the MutaMouse model for testing organ-specific mutagens.
- Subjects :
- Genetically modified mouse
Male
DNA damage
Chemistry
Mutagenicity Tests
Health, Toxicology and Mutagenesis
Injections, Subcutaneous
Mutant
Carbazoles
dBc
Gene mutation
Administration, Cutaneous
Molecular biology
Subcutaneous injection
Mice
Biochemistry
Lac Operon
Liver
Toxicity
Mutation
Genetics
Carcinogens
Animals
Carcinogen
Skin
Subjects
Details
- ISSN :
- 00275107
- Volume :
- 417
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Mutation research
- Accession number :
- edsair.doi.dedup.....a47189580c7c97c8c3ba89abcce958e2