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Versatile Polypeptide-Functionalized Plasmonic Paper as Synergistic Biocompatible and Antimicrobial Nanoplatform
- Source :
- Molecules, Molecules, Vol 25, Iss 3182, p 3182 (2020), Volume 25, Issue 14
- Publication Year :
- 2020
-
Abstract
- Nowadays, thanks to nanotechnological progress, which itself guides us more and more closely toward not only the efficient design of innovative nanomaterials or nanostructures, but to the improvement of their functionality, we benefit from an important asset in the battle against pathogenic illnesses. Herein, we report a versatile biocompatible plasmonic nanoplatform based on a Whatman paper incorporating positively-charged gold nanospherical particles via the immersion approach. The morphological characterization of the as-engineered-plasmonic paper was examined by SEM (scanning electron microscopy) and HRTEM (high-resolution transmission electron microscopy) investigations, while its surface chemical modification with a synthetic polypeptide, specifically RRWHRWWRR-NH2 (P2), was proved by monitoring the plasmonic response of loaded gold nanospheres and the emission signal of P2 via fluorescence spectroscopy. The as-functionalized plasmonic paper is non-cytotoxic towards BJ fibroblast human cells at bactericidal concentrations. Finally, the antimicrobial activity of the P2-functionalized plasmonic paper on both planktonic bacteria and biofilms was tested against two reference strains: Gram-positive Bacteria, i.e., Staphylococcus aureus and the Gram-negative Bacteria, i.e., Escherichia coli, determining microbial inhibition of up to 100% for planktonic bacteria. In line with the above presented nanoplatform&rsquo<br />s proper design, followed by their functionalization with active antimicrobial peptides, new roads can be open for determining antibiotic-free treatments against different relevant pathogens.
- Subjects :
- Paper
Staphylococcus aureus
Biocompatibility
Antimicrobial peptides
Pharmaceutical Science
Metal Nanoparticles
Nanotechnology
Biocompatible Materials
Article
Analytical Chemistry
Nanomaterials
Cell Line
lcsh:QD241-441
antimicrobial peptides
biocompatibility
lcsh:Organic chemistry
Drug Discovery
Escherichia coli
Humans
Physical and Theoretical Chemistry
High-resolution transmission electron microscopy
paper platform
antimicrobial activity
biology
Chemistry
Organic Chemistry
Biofilm
biology.organism_classification
Antimicrobial
gold nanospheres
Anti-Bacterial Agents
Chemistry (miscellaneous)
Biofilms
Molecular Medicine
Surface modification
Gold
Peptides
Bacteria
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....a469240391f9dc0e4d29738fbcfc09fd