Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy

Summary Background: Probiotics are live microorganisms, which as drugs or food supplements help to maintain health beneficial microbial balance in the digestive tract of a human or other host. Probiotics by their properties may help strengthen homeostasis and thus reduce side effects associated with cancer treatment. Experimental evidence suggests that probiotics might have beneficial effect on the toxicity of anticancer therapy. Methods: A computer-based literature search was carried out using PubMed (keywords: ‘‘probiotic’’ and ‘‘lactic acid bacteria’’ in association with the search terms ‘‘cancer’’ or ,,oncology’’ or ‘‘chemotherapy’’ or ‘‘radiation’’); data reported at international meetings were included. Results: Probiotics might have beneficial effects on some aspects of toxicity related to anticancer treatment especially radiation therapy. However, reported trials vary in utilized probiotic strains, dose of probiotics and vast majority of them are small trials with substantial risk of bias. Despite limited data, it seems that probiotic bacteria as live microorganisms could be safely administered even in the setting of neutropenia. Conclusions: Current evidence supporting probiotic use as adjunctive therapy to anticancer treatment is limited, especially in cancer patients treated with chemotherapy. Well designed clinical trials are needed to find true role of probiotics in oncology.