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Atrial endocardial expression of von Willebrand factor and thrombomodulin is associated with recurrence after minimally invasive surgical atrial fibrillation ablation
- Source :
- Interactive CardioVascular and Thoracic Surgery. 27:177-181
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- OBJECTIVES We retrospectively analysed data from non-valvular atrial fibrillation (AF) patients who underwent minimally invasive surgical AF ablation at our centre. Our purpose was to explore the atrial endocardial expression of von Willebrand factor (vWF) and thrombomodulin (TM) and their association with rhythm results after the procedure. METHODS From January 2014 to May 2015, 60 patients underwent minimally invasive surgical AF ablation at our centre. Left atrial appendage samples were obtained during the procedure and immunohistochemistry for endocardial markers including vWF and TM was performed and semi-quantitatively graded. All patients underwent postoperative rhythm documentation at 3, 6, 12 and 24 months. RESULTS At the 2-year interval, 49 (82%) patients maintained sinus rhythm, and all patients were asymptomatic. Univariate analysis shows that patients with AF recurrence have higher vWF score 2/3 and longer AF duration (P
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Time Factors
Thrombomodulin
medicine.medical_treatment
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Asymptomatic
03 medical and health sciences
0302 clinical medicine
Von Willebrand factor
Recurrence
Internal medicine
Atrial Fibrillation
von Willebrand Factor
Humans
Minimally Invasive Surgical Procedures
Medicine
Atrial Appendage
Sinus rhythm
Heart Atria
030212 general & internal medicine
Endocardium
Aged
Retrospective Studies
Univariate analysis
biology
business.industry
Atrial fibrillation
Middle Aged
medicine.disease
Ablation
Catheter Ablation
cardiovascular system
biology.protein
Cardiology
Female
Surgery
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 15699285 and 15699293
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Interactive CardioVascular and Thoracic Surgery
- Accession number :
- edsair.doi.dedup.....a44052369c4d431cf0d7a7328d991c27