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PBMC telomerase activity in depression and the response to electroconvulsive therapy
- Source :
- European Archives of Psychiatry and Clinical Neuroscience
- Publication Year :
- 2021
-
Abstract
- Telomerase, the DNA polymerase responsible for maintaining telomere length, has previously been implicated in depression and the response to antidepressant drugs. In this study, we aimed to compare telomerase activity in peripheral blood mononuclear cells between patients with severe depression recruited as part of the KEEP-WELL Trial (Ketamine for Depression Relapse Prevention Following ECT; NCT02414932) and age- and sex-matched healthy volunteers both at baseline/pre-ECT and at follow-up 1 month later for controls or in patients after a course of ECT. We found no differences in telomerase activity between patients with depression (n = 20) compared to healthy controls (n = 33) at baseline/pre-ECT, or between patients treated with ECT compared to controls at follow-up. In patients, telomerase activity was not associated with mood, as assessed by the 24-item Hamilton Rating Scale for Depression, or the duration of the current depressive episode. Additionally, we found no significant relationship between telomerase activity and exposure to recent or childhood adversity in either the patient or control groups. Overall, our results suggest that telomerase activity is not associated with depression, the therapeutic response to ECT, or exposure to adversity.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Telomerase
medicine.medical_treatment
Relapse prevention
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Electroconvulsive therapy
HAM-D24
Internal medicine
mental disorders
medicine
Humans
Pharmacology (medical)
Biological Psychiatry
Depression (differential diagnoses)
Original Paper
business.industry
Depression
PBMC
Hamilton Rating Scale for Depression
General Medicine
030227 psychiatry
Telomere
Psychiatry and Mental health
Mood
Treatment Outcome
Leukocytes, Mononuclear
Antidepressant
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14338491
- Volume :
- 271
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- European archives of psychiatry and clinical neuroscience
- Accession number :
- edsair.doi.dedup.....a44050717eb58dc9d8465b7510d9ae72