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Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres
- Source :
- International Journal of Pharmaceutics. 499:47-57
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The structure of solid drug delivery systems has considerable influence on drug release behaviors from particles and granules and also impacts other properties relevant to release characteristics such as taste. In this study, lipid-based microspheres of acetaminophen were prepared to mask the undesirable taste of drug and therefore to identify the optimal formulation for drug release. Synchrotron radiation X-ray computed microtomography (SR-μCT) was used to investigate the fine structural architectures of microspheres non-destructively at different sampling times during drug release test, which were simultaneously determined to quantitatively correlate the structural data with drug release behaviors. The results demonstrated that the polymeric formulation component, namely, cationic polymethacrylate (Eudragit E100), was the key factor to mask the bitter taste of acetaminophen by inhibiting immediate drug release thereby reducing the interaction intensity of the bitter material with the oral cavity taste buds. The structure and morphology of the microspheres were found to be influenced by the shape and particle size of the drug, which was also an important factor for taste-masking performance. The quantitative analysis generated detailed structural information which was correlated well with drug release behaviors. Thus, SR-μCT has been proved as a powerful tool to investigate the fine microstructure of particles and provides a new approach in the design of particles for taste masking.
- Subjects :
- Taste
X-ray microtomography
Drug Liberation
Materials science
Polymers
Chemistry, Pharmaceutical
Analytical chemistry
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Dissolution testing
Particle Size
Acetaminophen
chemistry.chemical_classification
X-Ray Microtomography
Polymer
021001 nanoscience & nanotechnology
Microstructure
Lipids
Microspheres
Acrylates
chemistry
Chemical engineering
Drug delivery
Particle size
0210 nano-technology
Synchrotrons
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 499
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....a4400035d078c707b6a52fa59756225b