Back to Search
Start Over
Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches
- Source :
- Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 17, Iss 3, Pp 476-483 (2021)
- Publication Year :
- 2021
- Publisher :
- Stolichnaya Izdatelskaya Kompaniyaizdat, 2021.
-
Abstract
- Heart failure with preserved ejection fraction (HFpEF) is a syndrome associated with high morbidity and mortality rates. Little progress has been in the treatment of this condition since its introduction some 30 years ago. It's accepted that HFpEF is heterogeneous in many ways, ethologically and phenotypically. The underlying mechanisms of the syndrome are not clear. Recently, it has been shown that the diagnostic criteria for HFpEF lacks sensitivity and specificity. Novel treatment approaches, which were developed based on current HFpEF pathophysiological concepts, did not show either clinical or prognostic benefit for patients. Therefore, there is an urgent need to revise current diagnostic approaches and to further investigate the underlying mechanisms. Recently, two novel diagnostic score systems were proposed: H2PEF and HFA-PEFF. Recently, a number of phase II and III randomized control trials have been completed. Here, the authors discuss the potential novel diagnostic approaches to HFpEF and treatment perspectives.
- Subjects :
- medicine.medical_specialty
RM1-950
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
High morbidity
0302 clinical medicine
Randomized controlled trial
law
medicine
Diseases of the circulatory (Cardiovascular) system
Pharmacology (medical)
030212 general & internal medicine
Intensive care medicine
chf
Ejection fraction
business.industry
medicine.disease
chronic heart failure
heart failure with intact ejection fraction
RC666-701
Heart failure
Therapeutics. Pharmacology
Cardiology and Cardiovascular Medicine
Heart failure with preserved ejection fraction
business
hfpef
Subjects
Details
- ISSN :
- 22253653 and 18196446
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Rational Pharmacotherapy in Cardiology
- Accession number :
- edsair.doi.dedup.....a437227612ae7820537df786f1db790b