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H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis

Authors :: Aleksey Shatunov
Karen E. Morrison
Kevin P. Kenna
Markus Weber
Christopher Shaw
Frank P. Diekstra
David Czell
Perry T.C. van Doormaal
Meinie Seelen
Wouter van Rheenen
Michael A. van Es
Anneke J. van der Kooi
Wim Robberecht
Bradley N. Smith
H. Jurgen Schelhaas
Leonard H. van den Berg
Marianne de Visser
Pamela J. Shaw
Ammar Al-Chalabi
Peter M. Andersen
Albert C. Ludolph
Russell L. McLaughlin
Stefan Waibel
Jan H. Veldink
Paul W.J. van Vught
Philip Van Damme
Orla Hardiman
ANS - Amsterdam Neuroscience
Neurology
Source :: Neurobiology of Aging; Vol 34, Neurobiology of aging, 34(5), 1517.e5-1517.e7. Elsevier Inc.
Publication Year :: 2013
Publisher :: ELSEVIER SCIENCE INC, 2013.
Abstract: The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeting this process. Evidence for this genetic association is, however, limited to several small studies. For this reason we studied the H63D polymorphism in a large European cohort including 3962 ALS patients and 5072 control subjects from 7 countries. After meta-analysis of previous studies and current findings we conclude that the H63D polymorphism in HFE is not associated with susceptibility to ALS, age at disease onset, or survival. ispartof: Neurobiology of aging vol:34 issue:5 pages:1517- ispartof: location:United States status: published