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Oral vitamin D3 5000 IU/day as an adjuvant in the treatment of atopic dermatitis: a randomized control trial
Oral vitamin D3 5000 IU/day as an adjuvant in the treatment of atopic dermatitis: a randomized control trial
- Source :
- International Journal of Dermatology. 57:1516-1520
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Vitamin D has immunomodulatory effects both in the innate and adaptive immune systems, and there is growing scientific evidence demonstrating its relevance in inflammatory processes such as AD.If vitamin D3 promotes the skin immune system, then it should improve the response to treatment of patients with AD.A randomized, double-blind placebo-controlled clinical trial was conducted, which included 65 patients with AD according to Hanifin-Rajka criteria and the severity scale (SCORAD). The patients were divided into two groups to receive either vitamin D3 5000 IU/day (n = 33) or placebo (n = 32), plus baseline therapy (topical steroid, soap substitute, and emollient) during 3 months.Fifty-eight of the 65 enrolled subjects were included in the analysis. At the end of the intervention, the treated group achieved higher levels of 25(OH)D (P 0.001). At week 12, those patients who registered serum levels of 25(OH)D ≥20 ng/ml, regardless of whether or not they had received supplementation, showed a lower SCORAD compared to those with levels20 ng/ml (P 0.001). Eighty percent of the patients with serum levels20 ng/ml (n = 9) had moderate-severe AD despite standard treatment. Vitamin D levels ≥20 ng/ml associated with baseline therapy strongly favored remission of atopic dermatitis (P = 0.03). No significant differences were found between patients with serum levels of ≥20 ng/ml vs. ≥30 ng/ml.Reaching serum levels of 25(OH)D 20 ng/ml in conjunction with standard therapy is sufficient to achieve a reduction in severity (SCORAD) in patients with AD.
- Subjects :
- Adult
Male
0301 basic medicine
Vitamin
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Administration, Oral
Dermatology
Administration, Cutaneous
Placebo
Severity of Illness Index
Gastroenterology
Dermatitis, Atopic
law.invention
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
law
Internal medicine
medicine
Vitamin D and neurology
Humans
SCORAD
Vitamin D
Child
Cholecalciferol
Emollients
medicine.diagnostic_test
business.industry
Vitamins
Atopic dermatitis
Middle Aged
medicine.disease
Clinical trial
030104 developmental biology
chemistry
Child, Preschool
Dietary Supplements
Drug Therapy, Combination
Female
Steroids
business
Topical steroid
Subjects
Details
- ISSN :
- 00119059
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- International Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....a41e9c746471abbb1b205c9611612016
- Full Text :
- https://doi.org/10.1111/ijd.14220