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A simple scoring system based on clinical factors related to pancreatic texture predicts postoperative pancreatic fistula preoperatively
- Source :
- HPB. 12(10):696-702
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- BackgroundPostoperative pancreatic fistula (POPF) is regarded as the most serious complication of pancreatic surgery. The preoperative risk stratification of patients by simple means is of interest in perioperative clinical management.MethodsBased on prospective data, we performed a risk factor analysis for POPF after pancreatoduodenectomy in 62 patients operated between 2006 and 2008 with special focus on clinical parameters that might serve to predict POPF. A predictive score was developed and validated in an independent second dataset of 279 patients operated between 2001 and 2010.ResultsSeveral pre- and intraoperative factors, as well as underlying pathology, showed significant univariate correlation with rate of POPF. Multivariate analysis (binary logistic regression) disclosed soft pancreatic texture (odds ratio [OR] 10.80, 95% confidence interval [CI] 1.80–62.20) and history of weight loss (OR 0.15, 95% CI 0.04–0.66) to be the only independent preoperative clinical factors influencing POPF rate. The subjective assessment of pancreatic hardness by the surgeon correlated highly with objective assessment of pancreatic fibrosis by the pathologist (r=−0.68, P
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Risk Assessment
Pancreaticoduodenectomy
Pancreatic Fistula
Predictive Value of Tests
Risk Factors
Germany
medicine
Odds Ratio
Health Status Indicators
Humans
Prospective Studies
pancreatic surgery
Risk factor
Prospective cohort study
Pancreas
Aged
Aged, 80 and over
pancreatoduodenectomy
Hepatology
business.industry
Patient Selection
Gastroenterology
Reproducibility of Results
Odds ratio
Perioperative
Original Articles
Middle Aged
medicine.disease
Surgery
medicine.anatomical_structure
Logistic Models
Treatment Outcome
Pancreatic fistula
Predictive value of tests
Female
business
postoperative pancreatic fistula
Subjects
Details
- ISSN :
- 1365182X
- Volume :
- 12
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- HPB
- Accession number :
- edsair.doi.dedup.....a40bbf5e87f657a06b4c6d3e4d9dcc92
- Full Text :
- https://doi.org/10.1111/j.1477-2574.2010.00239.x