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Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
- Source :
- Molecules, Vol 27, Iss 251, p 251 (2022), Molecules, Molecules; Volume 27; Issue 1; Pages: 251
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects of crude leaf extract of P. rubra were observed in rabbit aorta ring preparations. Hypotensive effects were measured using pressure and force transducers connected to the Power Lab data acquisition system. Furthermore, P. rubra displayed cardioprotective properties in rabbits when they were exposed to adrenaline-induced myocardial infarction. In comparison to the intoxicated group, the myocardial infarction model showed decreased troponin levels, CK-MB, LDH, ALT, ALP, AST, and CRP, as well as necrosis, apoptosis, oedema, and inflammatory cell enrollment. P. rubra has revealed good antioxidant properties and prolonged the noradrenaline intoxicated platelet adhesion. Its anticoagulant, vasorelaxant, and cardioprotective effects in both in vivo and ex vivo investigations are enabled by blocking L-type calcium channels, lowering adrenaline, induced oxidative stress, and tissue tear, justifying its therapeutic utility in cardiovascular disorders.
- Subjects :
- Cardiotonic Agents
Vasodilator Agents
cardioprotective
Pharmaceutical Science
Organic chemistry
Plumeria rbra
adrenaline
troponin
CRP
Article
Antioxidants
Analytical Chemistry
QD241-441
Drug Discovery
Animals
Physical and Theoretical Chemistry
Aorta
Chromatography, High Pressure Liquid
Plants, Medicinal
Dose-Response Relationship, Drug
Plant Extracts
Myocardium
Heart
Apocynaceae
Chemistry (miscellaneous)
Cardiovascular Diseases
Molecular Medicine
Rabbits
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 251
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....a405c6762f682ee3d1203214e0644bca