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Atypical Young-onset Dementia in Cerebral Thromboangiitis Obliterans: A Case Report
- Source :
- Alzheimer disease and associated disorders. 36(2)
- Publication Year :
- 2021
-
Abstract
- Young-onset dementia (YOD, age at onset below 45 y) has a broad differential diagnosis. We describe a 41-year-old man with atypical manifestations of YOD syndrome in cerebral thromoboangiitis obliterans (CTAO). Extensive antemortem workup including clinical assessment, laboratory investigations, neuroimaging, and genetic testing did not elucidate a diagnosis. Postmortem neuropathologic examination revealed cortical sickle-shaped granular atrophy, resulting from numerous remote infarcts and cortical microinfarcts that mainly affected the bilateral frontal and parietal lobe, confirming CTAO. Although CTAO is a rare cause of vascular dementia, it should be considered as one of the differentials in patients with YOD with a history of heavy smoking and presence of symmetric damages of watershed-territory on neuroimaging.
- Subjects :
- Adult
Male
Yod
Pathology
medicine.medical_specialty
Diagnosis, Differential
Neuroimaging
Medicine
Dementia
Humans
Vascular dementia
Genetic testing
medicine.diagnostic_test
business.industry
Dementia, Vascular
Parietal lobe
Thromboangiitis Obliterans
Syndrome
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Young onset dementia
Geriatrics and Gerontology
Differential diagnosis
business
Gerontology
Subjects
Details
- ISSN :
- 15464156
- Volume :
- 36
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Alzheimer disease and associated disorders
- Accession number :
- edsair.doi.dedup.....a3ff235aaf62eeb0b29e77d15a071451