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The Effect of Dialysis Modality and Membrane Performance on Native Immunity in Dialysis Patients
- Source :
- PRILOZI. 40:25-32
- Publication Year :
- 2019
- Publisher :
- Walter de Gruyter GmbH, 2019.
-
Abstract
- Chronic Kidney Disease (CKD) is characterized by immune activation with development of chronic inflammation. However, immune deficiency also exists in CKD patients. The number and the activity of Natural Killer cells (NK-cells) are influenced by the biocompatibility of various dialysis membranes. In this study we investigated the effect of dialysis modality and membrane type on NK-cell number and on phagocytic activity of neutrophils in patients on different dialysis methods. Sixty patients were included in the study and divided in three groups of 20 patients each. Patients on conventional hemodialysis using Low Flux membrane (cHD-LF) were included in Group I, patients on conventional dialysis using High Flux membrane (cHD-HF) were included in Group II and patients treated by on-line hemodiafiltration with High Flux polysulphone membrane (on-line HDF) were included in Group III. Native immunity was investigated using the number of NK-cells and the phagocytic activity of neutrophils. NK-cells count was significantly lower (p In conclusion, an impairment of the native immunity represented by NK cell number and phagocytic activity of neutrophils is observed in patients on dialysis. Dialysis modality and membrane performance do not influence the native immunity of dialyzed patients. However, parathormone blood levels are possibly involved in the development of immune system disturbances in such patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neutrophils
Polymers
Phagocytosis
medicine.medical_treatment
030232 urology & nephrology
Biocompatible Materials
Inflammation
Hemodiafiltration
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Immune system
Renal Dialysis
Immunity
Internal medicine
medicine
Humans
Sulfones
Renal Insufficiency, Chronic
Dialysis
Aged
Aged, 80 and over
business.industry
Membranes, Artificial
General Medicine
Middle Aged
medicine.disease
Immunity, Innate
Killer Cells, Natural
Membrane
Parathyroid Hormone
Female
Hemodialysis
medicine.symptom
business
Kidneys, Artificial
Kidney disease
Subjects
Details
- ISSN :
- 18578985 and 18579345
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- PRILOZI
- Accession number :
- edsair.doi.dedup.....a3d23eb04e3a4d48f03b29b5aec8c05e