Additional file 1 of A reciprocal feedback between colon cancer cells and Schwann cells promotes the proliferation and metastasis of colon cancer

Additional file 1 Fig. S1. Colon cancer cells promoted the proliferation and migration of Schwann cells by stimulating their secretion of NGF. Fig. S2. Exosomes derived from colon cancer cells facilitated the expression of NGF in Schwann cells via miR-21-5p. Fig. S3 miR-21-5p promoted the expression of NGF in Schwann cells through VHL/HIF-1α. Fig. S4. Schwann cells promoted the proliferation and metastasis of HCT116 cells. Fig. S5. Schwann cells facilitated the proliferation, migration, invasion, and EMT of colon cancer cells through NGF. Fig. S6. NGF facilitated the proliferation, migration, invasion, and EMT of SW480 cells. Fig. S7. NGF facilitated the proliferation, migration, invasion, and EMT of HCT116 cells. Fig. S8. NGF modulated the proliferation and metastasis of colon cancer cells by TrkA. Fig. S9. P75 did not involve in the NGF-induced proliferation and metastasis of colon cancer cells. Fig. S10. P75 did not involve in the NGF-induced proliferation and metastasis of colon cancer cells. Fig. S11. NGF modulated the proliferation and metastasis of colon cancer cells through ERK. Fig. S12. NGF modulated the proliferation and metastasis of colon cancer cells through ERK. Fig. S13. NGF modulated the proliferation and metastasis of colon cancer cells via ERK/ELK1. Fig. S14. NGF modulated the proliferation and metastasis of colon cancer cells via ERK/ELK1. Fig. S15. Schwann cells accelerated the tumorigenesis and metastasis of colon cancer in vivo. Fig. S16. The associated expression of NGF/TrkA/ERK/ELK1/ZEB1/miR-21-5p signaling in colon cancer tissues. Table S1. Clinicopathological characteristics of colon cancer patients. Table S2. Primers of genes in this research for qRT-PCR. Table S3. Details of primary antibodies applied in this study.