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Evaluation of selected South African plant species for antioxidant, antiplatelet, and cytotoxic activity
- Source :
- Pharmaceutical biology. 48(6)
- Publication Year :
- 2010
-
Abstract
- The antioxidant, antiplatelet, and cytoxoxic effects of seven South African plant extracts, namely, Combretum vendae A.E. van Wyk (Combretaceae), Commiphora harveyi (Engl.) Engl. (Burseraceae), Khaya anthotheca (Welm.) C.DC (Meliaceae), Kirkia wilmsii Engl. (Kirkiaceae), Loxostylis alata A. Spreng. ex Rchb. (Anacardiaceae), Ochna natalitia (Meisn.) Walp. (Ochnaceae), and Protorhus longifolia (Bernh. Ex C. Krauss) Engl. (Anacardiaceae), were evaluated using established in vitro assays. All the extracts showed comparably low toxicity except for the extract of C. harveyi that showed high hemagluttination assay titer value, which indicates toxicity. The extracts of P. longifolia, K. wilmsii, O. natalitia, L. alata, C. harveyi, and C. vendae exhibited antioxidant properties in the qualitative assay using DPPH. In the quantification of antioxidation using ABTS, only the extracts of P. longifolia, L. alata, and C. vendae showed antioxidant activity with respective TEAC values of 1.39, 1.94, and 2.08. Similarly, in the quantitative DPPH assay, L. alata (EC50, 3.58+/-0.23 microg/mL) and K. wilmsii (EC50, 3.57+/-0.41 microg/mL) did not differ significantly (por=0.05) from the control. K. anthotheca showed a higher EC50 (176.40+/-26.56 microg/mL) value, and differed significantly (por=0.05) from all the other extracts and control. In addition, the extracts of C. vendae and C. harveyi showed significant (por=0.05) antiplatelet activity and did not differ from the control (aspirin) with EC50 of 0.06+/-0.01 microg/mL and 0.19+/-0.00 microg/mL, respectively. Lower EC50 values in the antioxidant and antiplatelet studies are indicative of superior activity of the plant extract against oxidation and platelet aggregation.
- Subjects :
- Platelet Aggregation
Khaya anthotheca
DPPH
Pharmaceutical Science
Antioxidants
Protorhus longifolia
chemistry.chemical_compound
South Africa
Drug Discovery
Botany
Chlorocebus aethiops
Toxicity Tests
Animals
Anacardiaceae
Burseraceae
Horses
Vero Cells
Pharmacology
Combretaceae
ABTS
Meliaceae
Plants, Medicinal
biology
Dose-Response Relationship, Drug
Plant Extracts
General Medicine
biology.organism_classification
Complementary and alternative medicine
chemistry
Molecular Medicine
Platelet Aggregation Inhibitors
Subjects
Details
- ISSN :
- 17445116
- Volume :
- 48
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical biology
- Accession number :
- edsair.doi.dedup.....a3ba7c0829be8a38081c2ee1b10614f9