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From in vitro to in silico and back again: using biological and mathematical synergy to decipher breast cancer cell motility

Authors :
Silvia Escudero
Devin T. Rosenthal
Sofia D. Merajver
Alejandra C. Ventura
Harish Iyer
Ellen M. Arruda
Krishna Garikipati
Source :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2010
Publication Year :
2010

Abstract

The complexity of biological systems is often prohibitive in testing specific hypotheses from first physical principles. To circumvent these limitations we used biological data to inform a mathematical model of breast cancer cell motility. Using this in silico model we were able to accurately assess the influence of actin cytoskeletal architecture on the motility of a genetically modified breast cancer cell line. Furthermore, using the in silico model revealed a biological phenomenon that has not been previously described in live cell movement. Fusing biology and mathematics as presented here represents a new direction for biomedical research in which advances in each field synergistically drive discoveries in the other.

Details

ISSN :
23757477
Volume :
2010
Database :
OpenAIRE
Journal :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Accession number :
edsair.doi.dedup.....a39b75e4d530387276387349d696bde8