Back to Search
Start Over
Experiences and perceptions of patients with psoriatic arthritis participating in a trial of faecal microbiota transplantation: a nested qualitative study
- Source :
- BMJ Open, BMJ Open, Vol 11, Iss 3 (2021), Kragsnaes, M S, Sødergren, S T, Kjeldsen, J, Horn, H C, Munk, H L, Pedersen, J K, Klinkby, C S, De Wit, M, Ahlmark, N G, Tjørnhøj-Thomsen, T & Ellingsen, T 2021, ' Experiences and perceptions of patients with psoriatic arthritis participating in a trial of faecal microbiota transplantation : A nested qualitative study ', BMJ Open, vol. 11, no. 3, e039471 . https://doi.org/10.1136/bmjopen-2020-039471
- Publication Year :
- 2021
- Publisher :
- BMJ Publishing Group, 2021.
-
Abstract
- ObjectivesPatients’ first-hand experiences of faecal microbiota transplantation (FMT) performed in a rheumatological care setting have yet to be elucidated. The objectives were to explore participants’ perceptions of being part of an FMT trial thereby identifying potential trial participation effects and enlightening the patient perspective on the outlook for future FMT trials in rheumatic diseases.DesignIn a qualitative study nested within a double-blind, randomised, placebo-controlled trial (RCT) testing FMT as a potential new antirheumatic treatment, semistructured telephone interviews were conducted following the trial participants’ final 26-week visit. Qualitative researchers, who did not take part in the main trial, performed the interviews and the primary analysis. The experiences explored related to the conduct of the RCT and changes in the participants’ everyday life. The analysis was carried out using a thematic approach.SettingA Danish rheumatology university outpatient clinic with nationwide inclusion.ParticipantsThe study included 10 patients with psoriatic arthritis (PsA) who were unaware of their treatment allocation (FMT/sham transplantation) and completed the final 26-week trial visit.ResultsParticipation in the RCT influenced the patients’ understanding of PsA and induced positive changes in their everyday life. Renewed hopes for the future in addition to a feeling of enhanced care contributed to significant trial participation effects. FMT was deemed a tolerable and safe treatment.ConclusionsDiscrepancies between the clinical and the research setting should be considered when discussing the clinical relevance of the results of the RCT. Overall, patients with PsA who have participated in an RCT testing FMT find the treatment acceptable and safe encouraging more research into the field of microbiota-targeted interventions in rheumatic diseases.Trial registration numberNCT03058900; Pre-results.
- Subjects :
- medicine.medical_specialty
media_common.quotation_subject
rheumatology
Psychological intervention
law.invention
03 medical and health sciences
Psoriatic arthritis
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
Rheumatology
law
Internal medicine
medicine
therapeutics
Outpatient clinic
Humans
030212 general & internal medicine
media_common
030203 arthritis & rheumatology
business.industry
Arthritis, Psoriatic
General Medicine
Fecal Microbiota Transplantation
medicine.disease
Transplantation
Feeling
Antirheumatic Agents
Physical therapy
Medicine
Perception
business
qualitative research
Qualitative research
Subjects
Details
- Language :
- English
- ISSN :
- 20446055
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- BMJ Open
- Accession number :
- edsair.doi.dedup.....a399ce23199e453bf7413b70ae67ff75