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Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved
- Source :
- Autoimmunity, vol 51, iss 5
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Although autoimmune hepatitis (AIH) is more common in women and affects people of all races/ethnicities, there is currently limited information regarding the relationship between race/ethnicity and AIH, especially in the context of underserved populations. We aim to evaluate the relationship between race/ethnicity and AIH and better characterize its clinical features among different racial groups. We conducted a 15-year retrospective analysis, from January 2002 to June 2017, of patients seen at Zuckerberg San Francisco General Hospital (ZSFG). Sixty-three AIH patients and 2049 non-AIH controls were eligible for the study. The main predictor of interest was race/ethnicity, and the main outcome of interest was AIH diagnosis; other secondary measures recorded include clinical features such as ALT, bilirubin, and biopsy fibrosis at presentation. In a multivariable model adjusting for age and sex, we found that black (OR 9.6, 95% CI 1.8 to 178), Latino (OR 25.0, 95% CI 5.3 to 448), and Asian/Pacific Islander (API) (OR 10.8, 95% CI 2.2 to 196) race/ethnicity were associated with increased odds of an AIH diagnosis compared to the white reference group. Among people of color with AIH, there were no significant differences in baseline ALT (p = .45), total bilirubin at presentation (p = .06), fibrosis at presentation (p = .74), and hospitalization (p = .27). Race/ethnicity is an independent risk factor for AIH. The clinical features of AIH did not differ significantly among black, Latino, and API patients.
- Subjects :
- Male
Race ethnicity
Liver fibrosis
Ethnic group
Autoimmune hepatitis
Hepatitis
Race (biology)
0302 clinical medicine
Risk Factors
immune system diseases
Prevalence
80 and over
Ethnicity
Immunology and Allergy
race
liver fibrosis
Aged, 80 and over
Liver Disease
Middle Aged
Hepatitis, Autoimmune
Autoimmune liver disease
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Adult
medicine.medical_specialty
Immunology
liver
Vulnerable Populations
Article
outcomes research
Young Adult
03 medical and health sciences
Clinical Research
medicine
Humans
Risk factor
Retrospective Studies
Aged
business.industry
Racial Groups
Health Status Disparities
race/ethnicity
medicine.disease
digestive system diseases
Good Health and Well Being
San Francisco
Outcomes research
Digestive Diseases
business
Autoimmune
Demography
Subjects
Details
- ISSN :
- 1607842X and 08916934
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Autoimmunity
- Accession number :
- edsair.doi.dedup.....a383bbea17032c74e2f6f77ebde7a7c2