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Mitral Annular Remodeling to Treat Functional Mitral Regurgitation: A Pilot Acute Study in a Canine Model
- Source :
- The Heart Surgery Forum. 13:E247-E250
- Publication Year :
- 2010
- Publisher :
- Carden Jennings Publishing Co., 2010.
-
Abstract
- BACKGROUND The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). METHODS Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. RESULTS The injection improved MR grade from 3.4 +/- 0.8 to 1.3 +/- 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 +/- 0.4 cm to 2.9 +/- 0.3 cm; P = .039) and MR volume (20.6 +/- 7.3 mm3 to 5.2 +/- 2.2 mm3; P = .044). CONCLUSIONS A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.
- Subjects :
- medicine.medical_specialty
Beating heart
Myocardial ischemia
Heart Ventricles
Pilot Projects
Injections, Intramuscular
Severity of Illness Index
Hydrogel, Polyethylene Glycol Dimethacrylate
Dogs
Internal medicine
medicine
Animals
Functional mr
Postoperative Period
Mitral annulus
Hyaluronic Acid
Functional mitral regurgitation
business.industry
Mitral Valve Insufficiency
Papillary Muscles
Treatment Outcome
medicine.anatomical_structure
Echocardiography
Ventricle
Cardiology
Feasibility Studies
Surgery
Cardiology and Cardiovascular Medicine
business
Canine model
Hemodynamic instability
Subjects
Details
- ISSN :
- 15226662 and 10983511
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- The Heart Surgery Forum
- Accession number :
- edsair.doi.dedup.....a37f5c386864dcbfcf300b6b7d90974c