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Preparation of Inert Polystyrene Latex Particles as MicroRNA Delivery Vectors by Surfactant-Free RAFT Emulsion Polymerization
- Source :
- Biomacromolecules. 17:965-973
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- We present the preparation of 11 nm polyacrylamide-stabilized polystyrene latex particles for conjugation to a microRNA model by surfactant-free RAFT emulsion polymerization. Our synthetic strategy involved the preparation of amphiphilic polyacrylamide-block-polystyrene copolymers, which were able to self-assemble into polymeric micelles and "grow" into polystyrene latex particles. The surface of these sterically stabilized particles was postmodified with a disulfide-bearing linker for the attachment of the microRNA model, which can be released from the latex particles under reducing conditions. These nanoparticles offer the advantage of ease of preparation via a scaleable process, and the versatility of their synthesis makes them adaptable to a range of applications.
- Subjects :
- TP
Latex
Polymers and Plastics
Acrylic Resins
Emulsion polymerization
Nanoparticle
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Polymerization
Biomaterials
Surface-Active Agents
Polymer chemistry
Amphiphile
Materials Chemistry
Copolymer
QD
Drug Carriers
Chemistry
Raft
021001 nanoscience & nanotechnology
0104 chemical sciences
Drug Liberation
MicroRNAs
Chemical engineering
Nanoparticles
Polystyrenes
Emulsions
0210 nano-technology
Drug carrier
Oxidation-Reduction
Linker
Subjects
Details
- ISSN :
- 15264602 and 15257797
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Biomacromolecules
- Accession number :
- edsair.doi.dedup.....a37e70c37a985add3488bad54b61f68a