LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson's disease

Authors :: Francesca Condino
I.C. Cirò Candiano
Aldo Quattrone
Sara Carrideo
Grazia Annesi
Ferdinanda Annesi
Maurizio Morelli
S D’Asero
Sandra Paglionico
Patrizia Tarantino
Donatella Civitelli
EV De Marco
Pierfrancesco Pugliese
Giuseppe Nicoletti
Federico Rocca
Patrizia Spadafora
Source :: Clinical genetics 71 (2007): 367–370. doi:10.1111/j.1399-0004.2007.00771.x, info:cnr-pdr/source/autori:D. Civitelli; P. Tarantino; G. Nicoletti; I.C. Cirò Candiano; F. Annesi; E.V. De Marco; S. Carrideo; F.E. Rocca; F. Condino; P. Spadafora; P. Pugliese; S. D'Asero; M. Morelli; S. Paglionico; G. Annesi;A. Quattrone./titolo:LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson's disease/doi:10.1111%2Fj.1399-0004.2007.00771.x/rivista:Clinical genetics/anno:2007/pagina_da:367/pagina_a:370/intervallo_pagine:367–370/volume:71
Publication Year :: 2007
Abstract: Alterations in the leucine-rich kinase 2 gene (LRRK2; MIM *609007) have been shown to cause an autosomal dominant form of PARK8-linked parkinsonism (1, 2). Within this gene, the G6055A mutation (exon 41; Gly2019Ser) represents the most common mutation described to date both in familial and in sporadic forms of Parkinsons disease (PD).

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