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Strategies to rescue the consequences of inducible arginase-1 deficiency in mice
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 5, p e0125967 (2015), PLOS ONE
- Publication Year :
- 2015
-
Abstract
- Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body. Arginase-1 deficiency leads to hyperargininemia in mice and man with severe lethal consequences in the former and progressive neurological impairment to varying degrees in the latter. In a tamoxifen-induced arginase-1 deficient mouse model, mice succumb to the enzyme deficiency within 2 weeks after inducing the knockout and retain
- Subjects :
- Male
Ornithine
RNA, Untranslated
Hyperargininemia
lcsh:Medicine
Gene Expression
MOUSE
PHENOTYPE
chemistry.chemical_compound
Mice
Genes, Reporter
Transduction, Genetic
Transgenes
lcsh:Science
Mice, Knockout
Multidisciplinary
Sodium phenylbutyrate
Dependovirus
Arginase
Phenotype
Urea cycle
Knockout mouse
Gene Targeting
VECTORS
Female
medicine.drug
Research Article
EXPRESSION
Genetically modified mouse
medicine.medical_specialty
Transgene
Genetic Vectors
Longevity
Biology
Internal medicine
medicine
Diet, Protein-Restricted
Animals
MUTATIONS
lcsh:R
GENE-THERAPY
Biology and Life Sciences
HYPERARGININEMIA
UREA CYCLE DISORDERS
Molecular biology
MODEL
Endocrinology
chemistry
Genetic Loci
Dietary Supplements
lcsh:Q
Genes, Lethal
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....a36c8ed941fbc13a1f233b92fc8c5e98