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Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
- Source :
- Journal of the American Chemical Society. 144(2)
- Publication Year :
- 2022
-
Abstract
- Owing to its roles in human health and disease, the modification of nuclear, cytoplasmic, and mitochondrial proteins with O-linked
- Subjects :
- Proteomics
beta-Hexosaminidase alpha Chain
Brain
Hyaluronoglucosaminidase
General Chemistry
Biochemistry
Catalysis
Mass Spectrometry
Bridged Bicyclo Compounds
Structure-Activity Relationship
Colloid and Surface Chemistry
Antigens, Neoplasm
Catalytic Domain
Humans
Thiazolidines
Amino Acid Sequence
Enzyme Inhibitors
Peptides
Protein Processing, Post-Translational
Chromatography, High Pressure Liquid
Histone Acetyltransferases
Subjects
Details
- ISSN :
- 15205126
- Volume :
- 144
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....a3658ecaf8f20742f6ee3479a34644cc