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A Fully Integrated Paper-Microfluidic Electrochemical Device for Simultaneous Analysis of Physiologic Blood Ions
- Source :
- Sensors, Sensors (Basel, Switzerland), Sensors; Volume 18; Issue 1; Pages: 104
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- A fully integrated paper microfluidic electrochemical device equipped with three different cation permeable films is developed to determine blood ions (Cl−, Na+, K+, and Ca2+) at a time. These blood ions that are normally dissolved in the real human blood stream are essential for cell metabolisms and homeostasis in the human body. Abnormal concentration of blood ions causes many serious disorders. The optimized microfluidic device working without any external power source can directly and effectively separate human blood components, and subsequently detect a specific blood ion with minimized interference. The measured sensitivity to Cl−, K+, Na+, and Ca2+ are −47.71, 45.97, 51.06, and 19.46 in mV decade−1, respectively. Potentiometric responses of the microfluidic devices to blood serum samples are in the normal ranges of each cation, and comparable with responses from the commercial blood ion analyzer Abbott i-Stat.
- Subjects :
- Spectrum analyzer
potentiometric sensor
Microfluidics
Potentiometric titration
integrated paper microfluidic device
electrochemical sensor
02 engineering and technology
Electrochemistry
01 natural sciences
Biochemistry
Article
Ion
Analytical Chemistry
cation permeable film
Blood serum
Lab-On-A-Chip Devices
blood ion analysis
Humans
Potentiometric sensor
Electrical and Electronic Engineering
Instrumentation
Ions
Chromatography
Chemistry
010401 analytical chemistry
021001 nanoscience & nanotechnology
Atomic and Molecular Physics, and Optics
0104 chemical sciences
Electrochemical gas sensor
Potentiometry
0210 nano-technology
Subjects
Details
- ISSN :
- 14248220
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Sensors
- Accession number :
- edsair.doi.dedup.....a35f71d16900ff8c7830a799686b190d
- Full Text :
- https://doi.org/10.3390/s18010104