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Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
- Source :
- Brain Sciences, Vol 8, Iss 12, p 219 (2018), Brain Sciences, Volume 8, Issue 12
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR2 genes on the responses to the facial emotion recognition task in females. Postmenopausal healthy female volunteers were genotyped for the polymorphisms Xbal and PvuII of ESR1 and the polymorphism rs1256030 of ESR2. The effect of these polymorphisms on the response to the facial emotion recognition of the emotions happiness, sadness, disgust, anger, surprise, and fear was analyzed. Females carrying the P allele of the PvuII polymorphism or the X allele of the Xbal polymorphism of ESR1 easily recognized facial expressions of sadness that were more difficult for the women carrying the p allele or the x allele. They displayed higher accuracy, fast response time, more correct responses, and fewer omissions to complete the task, with a large effect size. Women carrying the ESR2 C allele of ESR2 showed a faster response time for recognizing facial expressions of anger. These findings link ESR1 and ESR2 polymorphisms in facial emotion recognition of negative emotions.
- Subjects :
- media_common.quotation_subject
Estrogen receptor
menopause
emotion
Anger
Bioinformatics
Article
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
Polymorphism (computer science)
Medicine
Allele
ESR2
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
media_common
Facial expression
business.industry
ESR1
General Neuroscience
Disgust
030227 psychiatry
Sadness
body regions
recognition
business
Estrogen receptor alpha
sadness
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20763425
- Volume :
- 8
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Brain Sciences
- Accession number :
- edsair.doi.dedup.....a34e4a742e24637bdc16d7bdd7b9513a