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Cornea in PCOS patients as a possible target of IGF-1 action and insulin resistance
- Source :
- Archives of Gynecology and Obstetrics. 290:1255-1263
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Previous studies suggest that serum IGF-1 is higher in women with polycystic ovary syndrome (PCOS). The ophthalmologic effects of IGF-1 excess have not yet been investigated in women with PCOS. The aim of the current study is to compare the corneal thickness of patients with PCOS and those of healthy subjects. Forty three patients with PCOS and 30 age-matched and gender-matched healthy individuals were enrolled in this cross-sectional study. Central corneal thickness (CCT) was measured in patients with PCOS and in healthy individuals with an ultrasound pachymeter. IGF-1 values were also determined in the study group. Women with PCOS had significantly higher levels of IGF-1 and homeostasis model assessment (HOMA-IR) levels than the control group. Right and left CCT measurements were higher in the PCOS group than in the control group. A positive correlation between IGF-1 and right and left CCT was identified in both groups. In multiple linear stepwise regression analyses, IGF-1 independently and positively associated with HOMA-IR in women with PCOS. A correlation between total testosterone and CCT was identified in the whole group. In multiple stepwise regression analyses, total testosterone independently and positively associated with left central corneal thickness in the whole group. These findings indicate that PCOS has target organ effects on the eye. Consequently, it can change central corneal thickness. Higher IGF-1 levels seem to be the main causes of increased corneal thickness. Insulin resistance in PCOS is one of the underlying causes and promotes increase in IGF-1. We suggest a careful and detailed corneal evaluation in PCOS patients to prevent the potential risk of increased CCT, in addition to the already-known complications.
- Subjects :
- Adult
medicine.medical_specialty
Corneal Pachymetry
genetic structures
endocrine system diseases
Cross-sectional study
Cornea
Young Adult
Insulin resistance
Hyperinsulinism
Internal medicine
Diabetes mellitus
medicine
Humans
Testosterone
Insulin-Like Growth Factor I
Corneal pachymetry
medicine.diagnostic_test
business.industry
Case-control study
nutritional and metabolic diseases
Obstetrics and Gynecology
General Medicine
Stepwise regression
medicine.disease
Polycystic ovary
eye diseases
Cross-Sectional Studies
Endocrinology
medicine.anatomical_structure
Diabetes Mellitus, Type 2
Case-Control Studies
Female
sense organs
Insulin Resistance
Hyperandrogenism
business
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 14320711 and 09320067
- Volume :
- 290
- Database :
- OpenAIRE
- Journal :
- Archives of Gynecology and Obstetrics
- Accession number :
- edsair.doi.dedup.....a33912c1f4d9ecc5de4ef6f7f6be9e03