Back to Search
Start Over
Histone variants at the transcription start-site
- Source :
- Trends in genetics : TIG. 30(5)
- Publication Year :
- 2014
-
Abstract
- The function of a eukaryotic cell crucially depends on accurate gene transcription to ensure the right genes are expressed whereas unrequired genes are repressed. Therefore, arguably, one of the most important regions in the genome is the transcription start-site (TSS) of protein-coding and non-coding genes. Until recently, understanding the mechanisms that define the location of the TSS and how it is created has largely focused on the role of DNA sequence-specific transcription factors. However, within the nucleus of a eukaryotic cell, transcription occurs in a highly compacted nucleosomal environment, and it is becoming clear that accessibility of the TSS is a key controlling step in transcriptional regulation. It has traditionally been thought that transcription can only proceed once the nucleosomes at the TSS have been evicted. New work suggests otherwise, however, and the focus of this review is to challenge this belief.
- Subjects :
- Genetics
Models, Molecular
genetic structures
General transcription factor
Pioneer factor
Eukaryotic transcription
Response element
Molecular Sequence Data
Promoter
RNA polymerase II
Transcription coregulator
Biology
Nucleosomes
Histones
biology.protein
Animals
Humans
Protein Isoforms
Amino Acid Sequence
Transcription Initiation Site
Promoter Regions, Genetic
Cis-regulatory module
Subjects
Details
- ISSN :
- 01689525
- Volume :
- 30
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Trends in genetics : TIG
- Accession number :
- edsair.doi.dedup.....a337adf10627150d04afe81c2ac14a5d