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Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction
- Source :
- Psychoneuroendocrinology. 85:56-62
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion. Methods In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure. Participants of the intervention group drank 1000 ml of mineral water within 10 min directly thereafter, compared to the participants of the control group who did not. Craving and plasma concentrations of acetylated ghrelin were measured ten times during the 120 min following the alcohol cue exposure session. Results In the intervention group, a significant decrease in acetylated ghrelin in plasma compared to the control group was observed. This decrease was correlated to a reduction in patients’ subjective level of craving. In the control group, no decrease of acetylated ghrelin in plasma and no association between alcohol craving and changes in plasma concentrations of acetylated ghrelin were observed. Conclusions Our results present new evidence that the modulation in the ghrelin system by oral water intake mediates the effects of volume intake with craving reduction in alcohol use disorders. Hence, in addition to pharmacological interventions with ghrelin antagonists, the reduction of physiological ghrelin secretion might be a target for future interventions in the treatment of alcohol craving.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
Alcohol
Craving
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Randomized controlled trial
law
Internal medicine
Outcome Assessment, Health Care
medicine
Humans
Biological Psychiatry
media_common
Endocrine and Autonomic Systems
business.industry
Drinking Water
Addiction
Stomach
digestive, oral, and skin physiology
Middle Aged
Ghrelin
Pathophysiology
Substance Withdrawal Syndrome
030227 psychiatry
Alcoholism
Psychiatry and Mental health
medicine.anatomical_structure
chemistry
medicine.symptom
business
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Ghrelin secretion
Subjects
Details
- ISSN :
- 03064530
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Psychoneuroendocrinology
- Accession number :
- edsair.doi.dedup.....a31d936680b4c58916fc34637021d225