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A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks’ gestation in pregnancies destined to deliver small for gestational age infants

Authors :
Tuong-Vi Nguyen
Teresa M. MacDonald
Emerson Keenan
Ping Cannon
Faith Andres
Natalie J. Hannan
Tu'uhevaha J Kaitu'u-Lino
Susan P. Walker
Georgia P. Wong
Stephen Tong
Source :
Placenta. 117:1-4
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

First trimester circulating ADAM12 is reduced in fetal growth restriction (FGR) and preeclampsia. We measured plasma ADAM12 at 36 weeks' gestation preceding diagnosis of term preeclampsia or delivery of a small for gestational age (SGA; birthweight10th centile) infant in two independent cohorts (Cohort 1 90 SGA, 41 preeclampsia, 862 controls; Cohort 2121 SGA 23 preeclampsia; 190 controls). ADAM12 was reduced with SGA in both cohorts (p = 0.0015 and 0.011 respectively), and further reduced with birthweight5th centile (p = 0.0013 and 0.0058 respectively). This validates ADAM12 as an SGA biomarker near term. Circulating ADAM12 preceding preeclampsia was not consistently altered.

Details

ISSN :
01434004
Volume :
117
Database :
OpenAIRE
Journal :
Placenta
Accession number :
edsair.doi.dedup.....a317b4880e932c44f6155893a1162bca