Back to Search
Start Over
A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks’ gestation in pregnancies destined to deliver small for gestational age infants
- Source :
- Placenta. 117:1-4
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- First trimester circulating ADAM12 is reduced in fetal growth restriction (FGR) and preeclampsia. We measured plasma ADAM12 at 36 weeks' gestation preceding diagnosis of term preeclampsia or delivery of a small for gestational age (SGA; birthweight10th centile) infant in two independent cohorts (Cohort 1 90 SGA, 41 preeclampsia, 862 controls; Cohort 2121 SGA 23 preeclampsia; 190 controls). ADAM12 was reduced with SGA in both cohorts (p = 0.0015 and 0.011 respectively), and further reduced with birthweight5th centile (p = 0.0013 and 0.0058 respectively). This validates ADAM12 as an SGA biomarker near term. Circulating ADAM12 preceding preeclampsia was not consistently altered.
- Subjects :
- medicine.medical_specialty
ADAM12
ADAM12 Protein
Preeclampsia
Pre-Eclampsia
Pregnancy
medicine
Fetal growth
Disintegrin
Humans
Prospective Studies
reproductive and urinary physiology
Metalloproteinase
biology
business.industry
Obstetrics
Infant, Newborn
Obstetrics and Gynecology
medicine.disease
female genital diseases and pregnancy complications
First trimester
Reproductive Medicine
Infant, Small for Gestational Age
embryonic structures
biology.protein
Small for gestational age
Gestation
Female
business
Biomarkers
Developmental Biology
Subjects
Details
- ISSN :
- 01434004
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Placenta
- Accession number :
- edsair.doi.dedup.....a317b4880e932c44f6155893a1162bca