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Rapid evolution of the human gene for cytochrome c oxidase subunit IV
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 89(12)
- Publication Year :
- 1992
-
Abstract
- We have compared the DNA sequences of nine mammalian genes for cytochrome c oxidase subunit IV (COX4 genes)--four expressed genes (human, bovine, rat, and mouse) and five pseudogenes (human, chimpanzee, orangutan, squirrel monkey, and bovine)--and constructed the sequence of the ancestral mammalian COX4 gene. By analyzing these sequences to determine the pattern and rate of nucleotide substitution in each branch of the evolutionary tree, we deduced that the human gene has evolved rapidly since the origin of the primate pseudogene approximately 41 million years ago, and we discuss the suggestion that this results from coevolution of nuclear and mitochondrial genes for cytochrome c oxidase.
- Subjects :
- Mitochondrial DNA
Nuclear gene
CYP3A
Macromolecular Substances
Pseudogene
Molecular Sequence Data
Biology
Polymerase Chain Reaction
Electron Transport Complex IV
Mice
Molecular evolution
Pongo pygmaeus
Sequence Homology, Nucleic Acid
Cytochrome c oxidase
Animals
Humans
Amino Acid Sequence
Gene
Saimiri
Genetics
Multidisciplinary
Nucleic acid sequence
Molecular biology
Biological Evolution
Rats
biology.protein
Cattle
Pseudogenes
Research Article
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 89
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....a30502789198a5d945ed01630580afa6