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Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis
- Source :
- Inflammatory Bowel Diseases, Chan, S S M, Luben, R, van Schaik, F, Oldenburg, B, Bueno-de-Mesquita, H B, Hallmans, G, Karling, P, Lindgren, S, Grip, O, Key, T, Crowe, F L, Bergmann, M M, Overvad, K, Palli, D, Masala, G, Khaw, K-T, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Olsen, A, Tjonneland, A, Kaaks, R, Tumino, R, Trichopoulou, A & Hart, A R 2014, ' Carbohydrate intake in the etiology of Crohn's disease and ulcerative colitis ', Inflammatory Bowel Diseases, vol. 20, no. 11, pp. 2013-21 . https://doi.org/10.1097/MIB.0000000000000168, Inflammatory Bowel Diseases; 20(11), pp 2013-2021 (2014)
- Publication Year :
- 2014
- Publisher :
- Umeå universitet, Näringsforskning, 2014.
-
Abstract
- Article first published online 25 September 2014. Supplemental Digital Content is Available in the Text.<br />Background: Diet may have a role in the etiology of inflammatory bowel disease. In previous studies, the associations between increased intakes of carbohydrates, sugar, starch, and inflammatory bowel disease are inconsistent. However, few prospective studies have investigated the associations between these macronutrients and incident Crohn's disease (CD) or ulcerative colitis (UC). Methods: A total of 401,326 men and women were recruited between 1991 and 1998. At recruitment, dietary intakes of carbohydrate, sugar, and starch were measured using validated food frequency questionnaires. The cohort was monitored identifying participants who developed incident CD or UC. Cases were matched with 4 controls, and odds ratios were calculated for quintiles of total carbohydrate, sugar, and starch intakes adjusted for total energy intake, body mass index, and smoking. Results: One hundred ten participants developed CD, and 244 participants developed UC during follow-up. The adjusted odds ratio for the highest versus the lowest quintiles of total carbohydrate intake for CD was 0.87, 95% CI = 0.24 to 3.12 and for UC 1.46, 95% CI = 0.62 to 3.46, with no significant trends across quintiles for either (CD, Ptrend = 0.70; UC, Ptrend = 0.41). Similarly, no associations were observed with intakes of total sugar (CD, Ptrend = 0.50; UC, Ptrend = 0.71) or starch (CD, Ptrend = 0.69; UC, Ptrend = 0.17). Conclusions: The lack of associations with these nutrients is in agreement with many case–control studies that have not identified associations with CD or UC. As there is biological plausibility for how specific carbohydrates could have an etiological role in inflammatory bowel disease, future epidemiological work should assess individual carbohydrates, although there does not seem to be a macronutrient effect.
- Subjects :
- Male
Gastroenterology
Inflammatory bowel disease
Body Mass Index
Crohn Disease
Risk Factors
Surveys and Questionnaires
Immunology and Allergy
Prospective Studies
Prospective cohort study
Aged, 80 and over
Crohn's disease
Incidence
starch
Middle Aged
Prognosis
Ulcerative colitis
Europe
sugar
Female
Adult
medicine.medical_specialty
etiology
Carbohydrates
Gastroenterology and Hepatology
Young Adult
Internal medicine
medicine
Humans
Colitis
Aged
ulcerative colitis
business.industry
Case-control study
Klinisk medicin
medicine.disease
digestive system diseases
Diet
carbohydrate
Case-Control Studies
Etiology
Colitis, Ulcerative
Clinical Medicine
Original Clinical Articles
Energy Intake
business
Body mass index
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15364844
- Database :
- OpenAIRE
- Journal :
- Inflammatory Bowel Diseases, Chan, S S M, Luben, R, van Schaik, F, Oldenburg, B, Bueno-de-Mesquita, H B, Hallmans, G, Karling, P, Lindgren, S, Grip, O, Key, T, Crowe, F L, Bergmann, M M, Overvad, K, Palli, D, Masala, G, Khaw, K-T, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Olsen, A, Tjonneland, A, Kaaks, R, Tumino, R, Trichopoulou, A & Hart, A R 2014, ' Carbohydrate intake in the etiology of Crohn's disease and ulcerative colitis ', Inflammatory Bowel Diseases, vol. 20, no. 11, pp. 2013-21 . https://doi.org/10.1097/MIB.0000000000000168, Inflammatory Bowel Diseases; 20(11), pp 2013-2021 (2014)
- Accession number :
- edsair.doi.dedup.....a2fdc379eae5587052b0766966418c6b