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ALTERED TRYPTOPHAN DEGRADATION LINKS CHRONIC INFLAMMATION TO FUNCTIONAL DECLINE & FRAILTY IN MICE AND HUMANS
- Source :
- Innovation in Aging
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- Chronic inflammation is associated with frailty and functional decline in older adults but the molecular mechanisms of this linkage are not well understood. We sought to examine metabolic and physiologic states associated with aging and frailty by analyzing the composition of metabolites in the blood of a population of community dwelling young, and older adults. Serum inflammatory cytokines and demographic and physiological covariates were collected in a set of community-dwelling adults age 20-97 (n=166). We then used LC/MS technology to profile 121 metabolites from five substance classes. Associations of the cytokines and metabolites with grip strength, walking speed, falls and outcomes were assessed in young, robust, pre-frail and frail participants. Age and frailty status positively correlated with IL6, TNFα, TNFαR1, IL1β (p
- Subjects :
- medicine.medical_specialty
Health (social science)
business.industry
Inflammation
Late Breaking Poster Session IV
Tryptophan degradation
Health Professions (miscellaneous)
Session Lb3620 (Late Breaking Poster)
Abstracts
Endocrinology
Internal medicine
Medicine
Functional decline
medicine.symptom
Life-span and Life-course Studies
business
Subjects
Details
- Language :
- English
- ISSN :
- 23995300
- Volume :
- 3
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- Innovation in Aging
- Accession number :
- edsair.doi.dedup.....a2fca8b8a35b05bbc0f98b515ecc6a87