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Sleep matters: Sleep functioning and course of illness in bipolar disorder
- Publication Year :
- 2016
-
Abstract
- Background: Few studies have prospectively examined the relationships of sleep with symptoms and functioning in bipolar disorder. Methods: The present study examined concurrent and prospective associations between total sleep time (TST) and sleep variability (SV) with symptom severity and functioning in a cohort of DSM-IV bipolar patients (N = 468) participating in the National Institute of Mental Health Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), all of whom were recovered at study entry. Results: Concurrent associations at study entry indicated that shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity. Mixed-effects regression modeling was used to examine prospective associations in the 196 patients for whom follow-up data were available. Consistent with findings at study entry, shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity over 12 months. Discussion: These findings highlight the importance of disrupted sleep patterns in the course of bipolar illness. © 2011 Elsevier B.V. All rights reserved.
- Subjects :
- Adult
Male
Sleep Wake Disorders
medicine.medical_specialty
Bipolar Disorder
Severity of Illness Index
Article
Cohort Studies
Young Adult
Severity of illness
mental disorders
medicine
Humans
Bipolar disorder
Longitudinal Studies
Prospective Studies
Prospective cohort study
Psychiatry
Depression (differential diagnoses)
Sleep disorder
Depressive Disorder
Course of illness
medicine.disease
Sleep in non-human animals
Mental health
Sleep time
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
Clinical Psychology
Cohort
Female
medicine.symptom
Psychology
Sleep
Mania
Cohort study
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a2f24e1fdcc092b54111043b2fb2e134