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Anal Transitional Zone Neoplasia in Patients with Familial Adenomatous Polyposis after Restorative Proctocolectomy and IPAA
- Source :
- Diseases of the Colon & Rectum. 56:808-814
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Background Restorative proctocolectomy and IPAA in patients with familial adenomatous polyposis may leave residual anal transitional zone mucosa that is prone to neoplasia. Objective The aim of this study was to evaluate the long-term control of neoplasia at the IPAA, the functional outcomes, and the influence of anastomotic technique on these results. Design : This research is a retrospective cohort study from a prospective database. Setting The investigation took place in a high-volume specialized colorectal surgery department. Patients Patients with familial adenomatous polyposis who underwent IPAA between 1983 and 2010 were included. Main outcome measures The primary outcomes measured were functional outcomes, quality of life, and the incidence of neoplasia in the anal transitional zone. Results Eighty-six patients underwent mucosectomy and 174 underwent stapled anastomosis with mean 155 ± 99 and 95 ± 70 months follow-up. Eighteen patients (20.9%) in the mucosectomy group and 59 patients (33.9%) in the stapled group developed anal transitional zone adenomas (p = 0.03). One of 86 (1.2%) patients undergoing mucosectomy and 3 of 174 (1.7%) patients undergoing stapled anastomosis developed cancer in the anal transitional zone (p > 0.05). Three of these patients underwent an abdominoperineal resection, but one who refused abdominoperineal resection underwent transanal excision with neoileoanal anastomosis. Patients undergoing a mucosectomy had a significantly higher rate of anastomotic stricture, but other complications were similar. Incontinence, seepage, and pad usage were higher in the mucosectomy group. Cleveland global quality-of-life score was 0.8 ± 0.2 in patients with handsewn anastomoses and 0.8 ± 0.3 in patients with a stapled anastomoses (p > 0.05). Limitations This study was limited by its nonrandomized retrospective design. Conclusions Risk for the development of adenomas in the anal transitional zone is higher after a stapled IPAA than after a mucosectomy with handsewn anastomosis. However, control of anal transitional zone neoplasia results in a similar risk of cancer development. Because the stapled procedure is associated with better long-term functional outcomes than a mucosectomy, stapled IPAA is the preferable procedure for most patients with familial adenomatous polyposis.
- Subjects :
- Adult
Male
Reoperation
medicine.medical_specialty
Time Factors
Colon
medicine.medical_treatment
Anastomosis
Familial adenomatous polyposis
Colon surgery
medicine
Humans
Intestinal Mucosa
Defecation
Anal Transitional Zone
Ohio
Retrospective Studies
Sutures
Abdominoperineal resection
Proctocolectomy
business.industry
Incidence
Proctocolectomy, Restorative
Suture Techniques
Gastroenterology
Neoplasms, Second Primary
Retrospective cohort study
Colonoscopy
General Medicine
Anus Neoplasms
medicine.disease
Surgery
Treatment Outcome
Adenomatous Polyposis Coli
Quality of Life
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00123706
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Diseases of the Colon & Rectum
- Accession number :
- edsair.doi.dedup.....a2eb1af25165da64601167b42e138e98