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Evolving role of magnetic resonance techniques in primary sclerosing cholangitis
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2019
-
Abstract
- Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis (PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in PSC. Magnetic resonance imaging/magnetic resonance cholangiopancreatography (MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance (MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC.
- Subjects :
- medicine.medical_specialty
Imaging biomarker
Cholangiopancreatography, Magnetic Resonance
Diffusion magnetic resonance imaging
Cholangitis, Sclerosing
Review
Magnetic resonance cholangiopancreatography
Primary sclerosing cholangitis
03 medical and health sciences
0302 clinical medicine
Endoscopic retrograde cholangiopancreatography
medicine
Clinical endpoint
Humans
Stage (cooking)
Cholangiopancreatography, Endoscopic Retrograde
medicine.diagnostic_test
business.industry
Gastroenterology
Magnetic resonance imaging
General Medicine
Prognosis
medicine.disease
Magnetic Resonance Imaging
Magnetic resonance elastography
030220 oncology & carcinogenesis
Disease Progression
030211 gastroenterology & hepatology
Bile Ducts
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 22192840 and 10079327
- Volume :
- 25
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....a2d1afc602820c0e5da7ac77ac50444b