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Red cell aplasia in myelofibrosis with myeloid metaplasia. A distinct functional and clinical entity
- Source :
- Cancer. 52(7)
- Publication Year :
- 1983
-
Abstract
- Three patients with myelofibrosis with myeloid metaplasia are described. All three presented with grave anemia and red cell aplasia. Erythroid failure was the functional characteristic of erythropoiesis as resulted from erythrokinetic studies. Bone marrow was hypercellular or normocellular with hyperplasia of granuloblasts and megakaryocytes. Despite absent or mild splenomegaly at diagnosis, massive splenomegaly associated with a leukoerythroblastic blood film developed during the course of the disease. A relative young age (42-47 years), a subacute course of the disease and terminal blast crisis in two of them were the prominent clinical features of the patients. The differentiation from acute or malignant myelofibrosis is discussed. The patients appear to be a distinct subset within myelofibrosis with myeloid metaplasia.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Myeloid
Erythrocytes
Anemia
Disease
Bone Marrow
hemic and lymphatic diseases
Metaplasia
medicine
Humans
Blood Transfusion
Myelofibrosis
Hyperplasia
Staining and Labeling
business.industry
Middle Aged
medicine.disease
medicine.anatomical_structure
Oncology
Primary Myelofibrosis
Erythropoiesis
Female
Bone marrow
medicine.symptom
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 0008543X
- Volume :
- 52
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....a2ccb47ee4e88df112d3f9889730ec2c