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Inflammatory polyradiculoneuropathies: Clinical and immunological aspects, current therapies, and future perspectives
- Source :
- European Journal of Inflammation, Vol 18 (2020)
- Publication Year :
- 2020
- Publisher :
- SAGE Publishing, 2020.
-
Abstract
- Inflammatory polyradiculoneuropathies are heterogeneous disorders characterized by immune-mediated leukocyte infiltration of peripheral nerves and nerve roots leading to demyelination or axonal degeneration or both. Inflammatory polyradiculoneuropathies can be divided into acute and chronic: Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy and their variants. Despite major advances in immunology and molecular biology have been made in the last years, the pathogenesis of these disorders is not completely understood. This review summarizes the current literature of the clinical features and pathogenic mechanisms of inflammatory polyradiculoneuropathies and focuses on current therapies and new potential treatment for the future.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Nerve root
Immunology
lcsh:Medicine
Chronic inflammatory demyelinating polyneuropathy
medicine.disease_cause
Guillain–Barré syndrome
inflammatory neuropathies
Autoimmunity
03 medical and health sciences
chronic inflammatory demyelinating polyneuropathy
0302 clinical medicine
peripheral nervous system
medicine
Immunology and Allergy
Guillain-Barre syndrome
business.industry
autoimmunity
lcsh:R
medicine.disease
Peripheral
030104 developmental biology
medicine.anatomical_structure
Peripheral nervous system
Settore MED/26 - Neurologia
neurophysiology
business
Infiltration (medical)
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20587392
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- European Journal of Inflammation
- Accession number :
- edsair.doi.dedup.....a2b6e65c8544df7557ae3590524da5d0