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Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction
- Source :
- Circulation journal : official journal of the Japanese Circulation Society. 78(4)
- Publication Year :
- 2014
-
Abstract
- BACKGROUND Thrombospondin-2 (TSP-2) is a matricellular protein found in human serum. Deletion of TSP-2 causes age-dependent dilated cardiomyopathy. We hypothesized that TSP-2 is a useful biomarker in patients with heart failure with reduced ejection fraction (HFrEF). METHODS AND RESULTS Serum TSP-2 was measured in 101 patients with HFrEF, and mortality and cardiovascular events were followed. Serum TSP-2 in the HFrEF group was significantly higher than in the non-HF group (n=17). Mean NYHA functional class was significantly higher in the high TSP-2 group (>median) than the low TSP-2 group (2.26 vs. 1.76, P=0.004). Circulating TSP-2 level was significantly associated with that of B-type natriuretic peptide (BNP; r=0.40, P
- Subjects :
- Male
endocrine system
medicine.medical_specialty
medicine.drug_class
Severity of Illness Index
Disease-Free Survival
immune system diseases
Predictive Value of Tests
Internal medicine
Natriuretic Peptide, Brain
medicine
Natriuretic peptide
Humans
Aged
Heart Failure
Framingham Risk Score
Ejection fraction
business.industry
Hazard ratio
Area under the curve
virus diseases
Dilated cardiomyopathy
Stroke Volume
General Medicine
Middle Aged
medicine.disease
Confidence interval
Survival Rate
Heart failure
Cardiology
Cardiology and Cardiovascular Medicine
business
Thrombospondins
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 13474820
- Volume :
- 78
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Accession number :
- edsair.doi.dedup.....a2b647f81637f9d239a039563eaf037f