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Thyroid hormones alter the adenine nucleotide hydrolysis in adult rat blood serum
- Source :
- BioFactors. 37:40-45
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The effects of ATP, ADP, and adenosine in the processes of platelet aggregation, vasodilatation, and coronary flow have been known for many years. The sequential hydrolysis of ATP to adenosine by soluble nucleotidases constitutes the main system for rapid inactivation of circulating adenine nucleotides. Thyroid disorders affect a number of biological factors including adenosine levels in different fractions. Then, we intend to investigate if the soluble nucleotidases responsible for the ATP, ADP, and AMP hydrolysis are affected by variations in the thyroid hormone levels in blood serum from adult rats. Hyperthyroidism was induced by daily intraperitoneal injections of L-thyroxine (T4) (2.5 and 10.0 μg/100 g body weight, respectively) for 7 or 14 days. Hypothyroidism was induced by thyroidectomy and methimazole (0.05%) added to their drinking water during 7 or 14 days. The treatments efficacy was confirmed by determination of hemodynamic parameters and cardiac hypertrophy evaluation. T4 treatment predominantly inhibited, and hypothyroidism (14 days after thyroidectomy) predominantly increased the ATP, ADP, and AMP hydrolysis in rat blood serum. These results suggest that both excess and deficiency of thyroid hormones can modulate the ATP diphosphohydrolase and 5'-nucleotidase activities in rat blood serum and consequently modulate the effects mediated by these enzymes and their products in vascular system.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Clinical Biochemistry
Hyperthyroidism
Biochemistry
Nucleotidases
Blood serum
Antithyroid Agents
Hypothyroidism
ATP hydrolysis
Adenine nucleotide
Internal medicine
medicine
Animals
Rats, Wistar
Enzyme Assays
Methimazole
Adenine Nucleotides
Chemistry
Hydrolysis
Thyroid
Hemodynamics
Thyroidectomy
General Medicine
Adenosine
Rats
Thyroxine
medicine.anatomical_structure
Endocrinology
Molecular Medicine
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 09516433
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- BioFactors
- Accession number :
- edsair.doi.dedup.....a2a50d7807e0db327ead680e3621d920