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Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum–Specific Atypical Memory B Cells
- Publication Year :
- 2017
- Publisher :
- AAI, 2017.
-
Abstract
- Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly understood. To address this, we compared B cell phenotypes and Abs specific for the Plasmodium falciparum vaccine candidate apical membrane Ag-1 (AMA1) in HIV-infected and uninfected adults living in Kenya. Surprisingly, HIV-1 infection was not associated with a difference in serum AMA1-specific Ab levels. HIV-infected individuals had a higher proportion of total atypical and total activated memory B cells (MBCs). Using an AMA1 tetramer to detect AMA1-specific B cells, HIV-infected individuals were also shown to have a higher proportion of AMA1-specific atypical MBCs. However, this proportional increase resulted in large part from a loss in the number of naive and resting MBCs rather than an increase in the number of atypical and activated cells. The loss of resting MBCs and naive B cells was mirrored in a population of cells specific for an Ag to which these individuals were unlikely to have been chronically exposed. Together, the data show that changes in P. falciparum Ag–specific B cell subsets in HIV-infected individuals mirror those in the overall B cell population, and suggest that the increased proportion of atypical MBC phenotypes found in HIV-1–infected individuals results from the loss of naive and resting MBCs.
- Subjects :
- 0301 basic medicine
Adult
Male
Adolescent
Immunology
Naive B cell
Population
Plasmodium falciparum
B-Lymphocyte Subsets
Protozoan Proteins
Antibodies, Protozoan
Antigens, Protozoan
HIV Infections
Lymphocyte Activation
Immunophenotyping
03 medical and health sciences
Mice
Young Adult
0302 clinical medicine
Antigen
parasitic diseases
medicine
Immunology and Allergy
Animals
Humans
Malaria, Falciparum
education
B cell
education.field_of_study
biology
Membrane Proteins
Apical membrane
biology.organism_classification
Flow Cytometry
Virology
Kenya
030104 developmental biology
medicine.anatomical_structure
Cross-Sectional Studies
biology.protein
Clinical and Human Immunology
Female
Antibody
Immunologic Memory
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a29ffafabf91d9dc7716d448384c2147