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Essential role for SUN5 in anchoring sperm head to the tail
- Source :
- eLife, Vol 6 (2017), eLife
- Publication Year :
- 2017
- Publisher :
- eLife Sciences Publications, Ltd, 2017.
-
Abstract
- SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function. Here, we generated Sun5−/− mice and found that male mice were infertile. Most Sun5-null spermatozoa displayed a globozoospermia-like phenotype but they were actually acephalic spermatozoa. Additional studies revealed that SUN5 was located in the neck of the spermatozoa, anchoring sperm head to the tail, and without functional SUN5 the sperm head to tail coupling apparatus was detached from nucleus during spermatid elongation. Finally, we found that healthy heterozygous offspring could be obtained via intracytoplasmic injection of Sun5-mutated sperm heads for both male mice and patients. Our studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility.
- Subjects :
- Male
0301 basic medicine
endocrine system
Mouse
Nuclear Envelope
QH301-705.5
Offspring
Science
Biology
ICSI
General Biochemistry, Genetics and Molecular Biology
Male infertility
03 medical and health sciences
0302 clinical medicine
Acephalic spermatozoa
medicine
Animals
Biology (General)
Nuclear membrane
Spermatogenesis
reproductive and urinary physiology
Mice, Knockout
sperm head-tail connection
General Immunology and Microbiology
Spermatid
urogenital system
General Neuroscience
Membrane Proteins
General Medicine
Anatomy
SUN5
medicine.disease
pseudo-globozoospermia
Sperm
Cell biology
Developmental Biology and Stem Cells
030104 developmental biology
medicine.anatomical_structure
Sperm Tail
Sperm Head
Medicine
Developmental biology
Nucleus
acephalic spermatozoa
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 2050084X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....a29f4f78b34d3360d7b109899086aa8d