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Impact of estimated-weight-base dose of alteplase in acute stroke treatment on clinical outcome
- Source :
- Journal of Clinical Neuroscience. 85:101-105
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Dosing of recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke treatment is often based on estimated body weight (BW) worldwide in routine clinical practice due to infeasible of accurate BW measurement. The aim of our study is to explore the impact of estimated BW when dosing rt-PA in acute ischemic stroke treatment on clinical outcome. Between January 2013 to May 2018, 126 acute ischemic stroke patients received intravenous rt-PA treatment based on estimated BW dosage were recruited. All patients had actual BW measured in ward after treatment. Based on the dosage of rt-PA given, patients were categorized into three groups, standard dose (0.8-1.0 mg/kg), overdose (1.0 mg/kg), and underdose (0.8 mg/kg). Among all 126 patients, 101 (80.2%) patients were treated with standard dose, 12 (9.5%) patients with overdose, and 13 (10.3%) patients with underdose of rt-PA respectively. There was no significant difference between demographic characteristics, pre-morbid risk factors, National Institutes of Health Stroke Scale (NIHSS) score at 24 h, NIHSS score at discharge, modified Rankin scale (mRS) within 0 to 2 in discharge or in 3 months after the event within the three groups. There was also no significant difference in hemorrhagic transformation and symptomatic intracranial hemorrhage (SICH). In conclusion, calculation of the dose of rt-PA based upon the estimated BW to treat acute ischemic stroke patients had no negative impact on the clinical outcome in our study.
- Subjects :
- Estimated Weight
03 medical and health sciences
0302 clinical medicine
Fibrinolytic Agents
Risk Factors
Physiology (medical)
Humans
Medicine
Drug Dosage Calculations
Thrombolytic Therapy
Routine clinical practice
Dosing
Recombinant tissue plasminogen activator
Acute ischemic stroke
Aged
Acute stroke
Dose-Response Relationship, Drug
Estimated Body Weight
business.industry
Body Weight
General Medicine
Middle Aged
Stroke
Treatment Outcome
Neurology
Tissue Plasminogen Activator
030220 oncology & carcinogenesis
Anesthesia
Female
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
After treatment
Subjects
Details
- ISSN :
- 09675868
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....a2936bafbfab3673872e85d5f8f64735